The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. KIF18B (kinesin family member 18B) is an 864 amino acid nuclear and cytoplasmic protein that belongs to the kinesin-like protein family. Containing one kinesin-motor domain, KIF18B is dominantly expressed in amygdala. During mitosis, KIF18B is suggested to be closely associated with astral microtubules emanating from the spindle pole during prometaphase and metaphase. KIF18B may play an important role in regulating cell division. KIF18B exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q21.31.